#4858 THE CHANGES OF THE C REACTIVE PROTEIN LEVEL DURING THE CRRT PROCEDURE

Abstract Background and Aims Continuous renal replacement therapy (CRRT) is recommended for critically ill patients (pts). Various infections sepsis often occur in these pts. In addition to being frequently used as inflammation parameter, C reactive protein (CRP) considered an important regulator of inflammatory processes may have active role atherosclerosis. Changes its level can indirect effects on processes. The aim this study was monitor change CRP during the CRRT procedure evaluate potential correlation between other monitored parameters. Method done observational, retrospectively prospective 154 pts, whom 343 procedures (proc) were performed. All pts treated at Clinics University Clinical Centre Vojvodina, by Dialysis Department, 2021. 2022. Procedures that lasted longer than 5 hours included. modalities CVVHD CVVHDF, with use different filters (EMiC2, Kit8/CiCa1000, oXiris, ST150), according device (MultiFiltrate, PrismaFlex) anticoagulation used. Demographic, clinical proc data collected from medical documentation. Blood laboratory testing sampled beginning end proc. An increase or decrease more 5% compared initial value significant. statistically processed. Results From 86.83% men, 13.17% women, average (avg.) age 56.52 years. proc, 41.69% CVVHD, 58.31% avg. duration 1033 min. Average ultrafiltration (UF) 2670mL, UF/hour 161.54mL/h. 176.25mg/l, 174.6mg/l 44.9% 43.44% a verified. did not significantly 11.66% (40/343). Patients' (p = 868) gender 752) affect which decreased (1084min) those (1023min), but difference significant 199). Prescribed dose 485), nor total UF 164) Hourly lower (148.18mL/h) (172.23mL/h) 000). modality had impact changes higher percentage (48.32%) seen CVVHDF (36.36%) 035). A found levels relation 011). EMiC2 filter most resulted (56.25%), filters. Septic condition present 85.91% ended 66.23% decrease, basal PCT fibrinogen 037, p 000 retrospectively). Initial number WBC differ two groups 424). Comorbidities such diabetes 489), malignancy 5) autoimmune disease 25) surgery precede 782). No association subsequent mortality 289) recovery function 808) found. Conclusion During procedure, influenced hourly ultrafiltration, modality, used, presence septic condition, high fibrinogen.